HDAC3 Inhibits Nrf2-GDF11 Signaling in TMJ OA Chondrocyte Adipogenesis

Posted: September 4, 2025
A study on temporomandibular joint osteoarthritis (TMJ OA) reveals that HDAC3 upregulation inhibits Nrf2-mediated transactivation of GDF11, leading to chondrocyte adipogenesis. Excessive biomechanical force accelerates this process, worsening cartilage degeneration. Therapeutic interventions with HDAC3 inhibitor RGFP966 and Nrf2 agonist Bardoxolone show promise in restoring GDF11 expression and mitigating adipogenesis in TMJ OA.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40914424/
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